CJC-1295 (No DAC)

CJC-1295 without DAC (Drug Affinity Complex), also known as Modified GRF (1-29) or Mod GRF 1-29, is a synthetic 29-amino-acid analogue of growth hormone-releasing hormone (GHRH). It features four amino acid substitutions (D-Ala², Gln⁸, Ala¹⁵, Leu²⁷) engineered to resist enzymatic degradation while maintaining strong GHRH receptor activity. Unlike the DAC-conjugated variant, this form promotes pulsatile growth hormone release patterns that more closely mimic endogenous physiological secretion, making it a widely used tool in GH-axis research.